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Oct 10, 20241 min read
A viral assembly inhibitor blocks SARS-CoV-2 replication in airway epithelial cells
https://nature.com/articles/s42003-024-06130-8 The ongoing evolution of SARS-CoV-2 to evade vaccines and therapeutics underlines the need...
Oct 10, 20241 min read
Inhibition of mRNA nuclear export promotes SARS-CoV-2 pathogenesis
https://www.pnas.org/doi/10.1073/pnas.2314166121 The nonstructural protein 1 (Nsp1) of SARS-CoV-2 (Severe Acute Respiratory Syndrome...
Oct 10, 20241 min read
SARS-CoV-2 Inhibitors Identified by Phenotypic Analysis of a Collection of Viral RNA-Binding Molecules
https://pubmed.ncbi.nlm.nih.gov/36558898/ Antiviral agents are needed for the treatment of SARS-CoV-2 infections and to control other...
Oct 10, 20241 min read
Protocol for production and purification of SARS-CoV-2 3CLpro
https://pubmed.ncbi.nlm.nih.gov/37235475/ 3CLpro protease from SARS-CoV-2 is a primary target for COVID-19 antiviral drug development....
Oct 10, 20241 min read
Structural similarities between SARS-CoV2 3CLpro and other viral proteases suggest potential lead molecules for developing broad spectrum antivirals
https://pubmed.ncbi.nlm.nih.gov/36353143/ Considering the significant impact of the recent COVID-19 outbreak, development of...
Oct 10, 20241 min read
Ancestral, Delta, and Omicron (BA.1) SARS-CoV-2 strains are dependent on serine proteases for entry throughout the human respiratory tract
https://pubmed.ncbi.nlm.nih.gov/37769654/ The SARS-CoV-2 Omicron BA.1 variant emerged in late 2021 and became the globally dominant...
Oct 10, 20241 min read
Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment
https://pubmed.ncbi.nlm.nih.gov/37315523/ Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily infects the respiratory...
Oct 10, 20242 min read
Identification of In Vitro Inhibitors of Monkeypox Replication
Identification of In Vitro Inhibitors of Monkeypox Replication - PubMed ( nih.gov ) Monkeypox virus (MPXV) infections in humans have...
Oct 10, 20241 min read
Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(24)00218-X Further development of direct-acting antiviral...
Dec 5, 20221 min read
Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection
https://pubmed.ncbi.nlm.nih.gov/36175661/
Dec 5, 20221 min read
SARS-CoV-2 Inhibitors Identified by Phenotypic Analysis Collection of Viral RNA-Binding Molecules
https://www.mdpi.com/1424-8247/15/12/1448