The SARS-CoV-2 Omicron BA.1 variant emerged in late 2021 and became the globally dominant variant by January 2022. Authentic virus and pseudovirus systems have shown Omicron spike has an increased dependence on the endosomal pathway for entry.
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See Allhttps://nature.com/articles/s42003-024-06130-8 The ongoing evolution of SARS-CoV-2 to evade vaccines and therapeutics underlines the need...
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https://www.pnas.org/doi/10.1073/pnas.2314166121 The nonstructural protein 1 (Nsp1) of SARS-CoV-2 (Severe Acute Respiratory Syndrome...
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https://pubmed.ncbi.nlm.nih.gov/36558898/ Antiviral agents are needed for the treatment of SARS-CoV-2 infections and to control other...
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