The Center for Antiviral Medicines & Pandemic Preparedness (CAMPP) will draw upon world class drug discovery infrastructure embedded in an academic setting, as well as a network of expert virologists, chemists, pharmacologists, structural and computational biologists, and significant prior investments in global health drug discovery, to generate a more substantial pool of antiviral lead series and candidate drugs with the potential to address the immediate threat of SARS-CoV-2 and provide antiviral drug candidates that might quickly pivot to address future outbreaks or pandemics of other viruses of pandemic concern, including other coronaviruses, flaviviruses, and filoviruses.